ISEV Position Papers and Guidelines

2024

• Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (JEV Feb 2024)
• Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies (JEV Jan 2024)

2023

• MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research (JEV Dec 2023)
• Cell culture-derived extracellular vesicles: Considerations for reporting cell culturing parameters (JEB Oct 2023)
• Guidelines for the purification and characterization of extracellular vesicles of parasites (JEB Oct 2023)
• A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, "Therapeutic advances with native and engineered human extracellular vesicles" (Cytotherapy Aug 2023)
• A compendium of single extracellular vesicle flow cytometry (ISEV-ISAC-ISTH working group on flow cytometry, JEV Feb 2023)
• The quick reference card "Storage of urinary EVs" - A practical guideline tool for research and clinical laboratories (JEV Mar 2023)

2022

• Minimum information to report about a flow cytometry experiment on extracellular vesicles: Communication from the ISTH SSC subcommittee on vascular biology (JTH Jan 2022)
• Extracellular Vesicles as Novel Players in Kidney Disease (JASN Mar 2022)
• Reproducibility of extracellular vesicle research (EJCB Aug 2022)

2021

• Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles (Urinary task force position paper, JEV May 2021)

2020

• MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments (ISEV-ISAC-ISTH working group on flow cytometry, JEV Feb 2020)
• ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19 (Cytotherapy May 2020)
• Patient information and safety notice: extracellular vesicles/exosomes and unproven therapies (ISEV Aug 2020)
• Methods for separation and characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee (Cells Aug 2020)
• Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration (JEV Sep 2020)
• MIFlowCyt-EV: The Next Chapter in the Reporting and Reliability of Single Extracellular Vesicle Flow Cytometry Experiments (Cytometry A. Nov 2020) 
• Rigor and standardization of extracellular vesicle research: Paving the road towards robustness (JEV Dec 2020)

2019

• Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles (JEV Aug 2019)
• FDA Public Safety Notification on Exosome Products (US FDA Dec 2019)

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